Back to Search
Start Over
Improved penicillin susceptibility of Streptococcus pneumoniae and increased penicillin consumption in Japan, 2013-18.
- Source :
-
PloS one [PLoS One] 2020 Oct 22; Vol. 15 (10), pp. e0240655. Date of Electronic Publication: 2020 Oct 22 (Print Publication: 2020). - Publication Year :
- 2020
-
Abstract
- Objectives: To examine the association between penicillin susceptibility of Streptococcus pneumoniae and penicillin consumption in Japan.<br />Methods: We used Japan Nosocomial Infection Surveillance data on the susceptibility of S. pneumoniae and sales data obtained from IQVIA Services Japan K.K. for penicillin consumption. We analysed both sets of data by decomposing them into seasonality and chronological trend components. The cross-correlation function was checked using Spearman's rank correlation coefficient to examine the correlation between susceptibility and consumption.<br />Results: After adjusting for seasonality, the susceptibility of S. pneumoniae to penicillins gradually improved (55.7% in 2013 and 60.6% in 2018, respectively) and penicillin consumption increased during the same period (0.76 defined daily doses per 1,000 inhabitants per day [DID] in 2013, and 0.89 DID in 2018). The results showed positive cross-correlation (coefficient 0.801, p-value < 0.001). In contrast, cephalosporin consumption decreased (3.91 DID in 2013 and 3.19 DID in 2018) and showed negative cross-correlation with susceptibility of S. pneumoniae to penicillins (coefficient -0.981, p-value < 0.001).<br />Conclusions: The rates of penicillin-susceptible S. pneumoniae isolates did not negatively correlate with penicillin consumption at the population level. Increased penicillin consumption might not impair the penicillin susceptibility of S. pneumoniae.<br />Competing Interests: The authors have declared that no competing interests exist.
- Subjects :
- Anti-Bacterial Agents therapeutic use
Cephalosporins therapeutic use
Humans
Japan epidemiology
Penicillins therapeutic use
Anti-Bacterial Agents pharmacology
Penicillin Resistance
Penicillins pharmacology
Pneumococcal Infections drug therapy
Pneumococcal Infections epidemiology
Streptococcus pneumoniae drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 15
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 33091045
- Full Text :
- https://doi.org/10.1371/journal.pone.0240655