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Selective photo-ablation of glioma cells using an enzyme activatable photosensitizer.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2020 Nov 18; Vol. 56 (89), pp. 13860-13863. Date of Electronic Publication: 2020 Oct 22. - Publication Year :
- 2020
-
Abstract
- An activatable photosensitizer based on methylene blue was developed and validated for its efficacy in the selective killing of γ-glutamyl transpeptidase expressing cells. The <superscript>1</superscript> O <subscript>2</subscript> deactivation via bond breakage, rapid in situ enzymatic photosensitivity conversion, long lysosomal retention, and nucleus relocation collectively contribute to its strong and selective photodynamic effects.
- Subjects :
- Animals
Antineoplastic Agents chemistry
Cell Line, Tumor
Cell Proliferation drug effects
Cell Survival drug effects
Drug Screening Assays, Antitumor
Enzyme Activators chemistry
Glioma metabolism
Glioma pathology
Humans
Methylene Blue chemistry
Molecular Structure
Optical Imaging
Photosensitizing Agents chemistry
Rats
Antineoplastic Agents pharmacology
Enzyme Activators pharmacology
Glioma drug therapy
Methylene Blue pharmacology
Photochemotherapy
Photosensitizing Agents pharmacology
gamma-Glutamyltransferase metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 56
- Issue :
- 89
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 33089272
- Full Text :
- https://doi.org/10.1039/d0cc05707j