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Oxygen therapeutic agents to target hypoxia in cancer treatment.
- Source :
-
Current opinion in pharmacology [Curr Opin Pharmacol] 2020 Aug; Vol. 53, pp. 146-151. Date of Electronic Publication: 2020 Oct 18. - Publication Year :
- 2020
-
Abstract
- Solid tumors have abnormal microcirculation that limits oxygen delivery and leads to a hypoxic tumor microenvironment. Tumor hypoxia stabilizes the transcription factor HIF-1α that can trigger immunosuppression through A2A adenosine receptors which prevents immune attack on tumors. In addition, success of chemotherapy and radiation therapy appears to be dependent on oxygen levels. Two main pharmaceutical classes of agents (hemoglobin based and perfluorocarbon man-made carbon oils) have been tested in tumor models as enhanced oxygen therapeutics. This article will review how these agents function as well as examine work to date with both drug classes.<br /> (Copyright © 2020 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1471-4973
- Volume :
- 53
- Database :
- MEDLINE
- Journal :
- Current opinion in pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 33086188
- Full Text :
- https://doi.org/10.1016/j.coph.2020.09.009