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Community health status and outcomes after allogeneic hematopoietic cell transplantation in the United States.
- Source :
-
Cancer [Cancer] 2021 Feb 15; Vol. 127 (4), pp. 609-618. Date of Electronic Publication: 2020 Oct 21. - Publication Year :
- 2021
-
Abstract
- Background: The association of community factors and outcomes after hematopoietic cell transplantation (HCT) has not been comprehensively described. Using the County Health Rankings and Roadmaps (CHRR) and the Center for International Blood and Marrow Transplant Research (CIBMTR), this study evaluated the impact of community health status on allogeneic HCT outcomes.<br />Methods: This study included 18,544 adult allogeneic HCT recipients reported to the CIBMTR by 170 US centers in 2014-2016. Sociodemographic, environmental, and community indicators were derived from the CHRR, an aggregate community risk score was created, and scores were assigned to each patient (patient community risk score [PCS]) and transplant center (center community risk score [CCS]). Higher scores indicated less healthy communities. The impact of PCS and CCS on patient outcomes after allogeneic HCT was studied.<br />Results: The median age was 55 years (range, 18-83 years). The median PCS was -0.21 (range, -1.37 to 2.10; standard deviation [SD], 0.42), and the median CCS was -0.13 (range, -1.04 to 0.96; SD, 0.40). In multivariable analyses, a higher PCS was associated with inferior survival (hazard ratio [HR] per 1 SD increase, 1.04; 99% CI, 1.00-1.08; P = .0089). Among hematologic malignancies, a tendency toward inferior survival was observed with a higher PCS (HR, 1.04; 99% CI, 1.00-1.08; P = .0102); a higher PCS was associated with higher nonrelapse mortality (NRM; HR, 1.08; 99% CI, 1.02-1.15; P = .0004). CCS was not significantly associated with survival, relapse, or NRM.<br />Conclusions: Patients residing in counties with a worse community health status have inferior survival as a result of an increased risk of NRM after allogeneic HCT. There was no association between the community health status of the transplant center location and allogeneic HCT outcomes.<br /> (© 2020 American Cancer Society.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Female
Hematologic Neoplasms pathology
Hematologic Neoplasms therapy
Humans
Male
Middle Aged
Neoplasm Recurrence, Local epidemiology
Neoplasm Recurrence, Local therapy
Public Health statistics & numerical data
Risk Factors
Treatment Outcome
United States epidemiology
Young Adult
Community Health Planning
Hematologic Neoplasms epidemiology
Hematopoietic Stem Cell Transplantation statistics & numerical data
Transplantation, Homologous statistics & numerical data
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0142
- Volume :
- 127
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 33085090
- Full Text :
- https://doi.org/10.1002/cncr.33232