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Galuteolin Inhibited Autophagy for Neuroprotection Against Transient Focal Cerebral Ischemia in Rats.
- Source :
-
Neuromolecular medicine [Neuromolecular Med] 2020 Dec; Vol. 22 (4), pp. 493-502. Date of Electronic Publication: 2020 Oct 21. - Publication Year :
- 2020
-
Abstract
- Galuteolin, a Chinese herbal medicine, purified from Lonicera Japonica. In this study, we aimed to investigate the neuroprotective effect of galuteolin against cerebral ischemia/reperfusion (I/R) injury. We administered galuteolin or galuteolin and rapamycin to rats which had middle cerebral artery occlusion/reperfusion (MCAO/R). A series of characterizations were carried out to monitor the outcomes of galuteolin in I/R rats regarding the infarct volumes, neurological deficits, and brain water, as well as its effect on neuroprotection and autophagy. It was found that galuteolin significantly reduced the infarct volume, brain water content, and the neurological deficits in a dose-dependent manner. Neuron damages were decreased in the hippocampal carotid artery 1 pyramidal layer by galuteolin. The expression levels of neuron-specific enolase (NSE) increased after galuteolin treatment. Galuteolin significantly decreased the expression levels of autophagy-related proteins. In addition, galuteolin decreased rapamycin-related neuron damages and activations of autophagy in I/R rats. Our data suggested that galuteolin can inhibit ischemic brain injuries through the regulation of autophagy-related indicators in I/R.
- Subjects :
- Animals
Body Water
Cerebral Infarction drug therapy
Cerebral Infarction pathology
Dose-Response Relationship, Drug
Drugs, Chinese Herbal therapeutic use
Glucosides therapeutic use
Luteolin therapeutic use
Male
Molecular Structure
Neurons drug effects
Neuroprotective Agents therapeutic use
Rats
Rats, Sprague-Dawley
Reperfusion Injury drug therapy
Sirolimus toxicity
Autophagy drug effects
Drugs, Chinese Herbal pharmacology
Glucosides pharmacology
Infarction, Middle Cerebral Artery drug therapy
Ischemic Attack, Transient drug therapy
Luteolin pharmacology
Neuroprotective Agents pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1559-1174
- Volume :
- 22
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Neuromolecular medicine
- Publication Type :
- Academic Journal
- Accession number :
- 33085067
- Full Text :
- https://doi.org/10.1007/s12017-020-08606-2