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A single mutation in Crimean-Congo hemorrhagic fever virus discovered in ticks impairs infectivity in human cells.
- Source :
-
ELife [Elife] 2020 Oct 21; Vol. 9. Date of Electronic Publication: 2020 Oct 21. - Publication Year :
- 2020
-
Abstract
- Crimean-Congo hemorrhagic fever (CCHF) is the most widely distributed tick-borne viral infection in the world. Strikingly, reported mortality rates for CCHF are extremely variable, ranging from 5% to 80% (Whitehouse, 2004). CCHF virus (CCHFV, Nairoviridae ) exhibits extensive genomic sequence diversity across strains (Deyde et al., 2006; Sherifi et al., 2014). It is currently unknown if genomic diversity is a factor contributing to variation in its pathogenicity. We obtained complete genome sequences of CCHFV directly from the tick reservoir. These new strains belong to a solitary lineage named Europe 2 that is circumstantially reputed to be less pathogenic than the epidemic strains from Europe 1 lineage. We identified a single tick-specific amino acid variant in the viral glycoprotein region that dramatically reduces its fusion activity in human cells, providing evidence that a glycoprotein precursor variant, present in ticks, has severely impaired function in human cells.<br />Competing Interests: BH, FS, VO, AK, MM, CD, SN, CS, SJ, ÉB No competing interests declared
- Subjects :
- Amino Acid Substitution genetics
Animals
Arachnid Vectors virology
Europe
Genetic Variation genetics
Genome, Viral genetics
Hemorrhagic Fever Virus, Crimean-Congo genetics
Hemorrhagic Fever, Crimean virology
Humans
Phylogeny
Ticks virology
Hemorrhagic Fever Virus, Crimean-Congo pathogenicity
Subjects
Details
- Language :
- English
- ISSN :
- 2050-084X
- Volume :
- 9
- Database :
- MEDLINE
- Journal :
- ELife
- Publication Type :
- Academic Journal
- Accession number :
- 33084573
- Full Text :
- https://doi.org/10.7554/eLife.50999