Development of DHQ-based chemical biology probe to profile cellular targets for HBV.

Authors :: Zhang Q
Huang J
Chow HY
Wang J
Zhang Y
Fung YME
Ren Q
Li X
Source :: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2020 Dec 01; Vol. 30 (23), pp. 127615. Date of Electronic Publication: 2020 Oct 17.
Publication Year :: 2020
Abstract: Chronic hepatitis B virus (HBV) infection has been a serious public health burden worldwide. Current anti-HBV therapies could not eliminate HBV ultimately. Considering the characteristics of HBV, it is impossible to be entirely cured based on current therapies. Therefore, it is urgently needed to develop novel therapeutic agents with new mechanism of action. The dihydroquinolizinone (DHQ) derivatives exhibited potent anti-HBV activity by decreasing HBV DNA and HBsAg level in an obscure mechanism of action. In this study, we have optimized the DHQ scaffold, developed the photoaffinity probe, with which to identify potential binding proteins.<br /> (Copyright © 2020 Elsevier Ltd. All rights reserved.)

Subjects :: Antiviral Agents chemical synthesis
Chromatography, Liquid
Click Chemistry
Molecular Structure
Photoaffinity Labels chemical synthesis
Proteome analysis
Proteome chemistry
Proteomics
Quinolizines chemical synthesis
Structure-Activity Relationship
Tandem Mass Spectrometry
Viral Proteins chemistry
Antiviral Agents pharmacology
Hepatitis B virus drug effects
Photoaffinity Labels pharmacology
Quinolizines pharmacology
Viral Proteins analysis

Full Text Access

Tools