Rhamnose modified bovine serum albumin as a carrier protein promotes the immune response against sTn antigen.

Authors :: Lin H
Hong H
Wang J
Li C
Zhou Z
Wu Z
Source :: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2020 Nov 21; Vol. 56 (90), pp. 13959-13962. Date of Electronic Publication: 2020 Oct 20.
Publication Year :: 2020
Abstract: Rhamnose and sTn antigen were co-conjugated to bovine serum albumin (BSA), a weakly immunogenic carrier protein, for cancer vaccine development. The immune responses against sTn have been significantly augmented with the involvement of Rha-specific antibodies to enhance antigen uptake.

Subjects :: Animals
Antigen-Antibody Reactions
Antigens, Tumor-Associated, Carbohydrate genetics
Cattle
Humans
Immunity
MCF-7 Cells
Mice
Molecular Conformation
Rhamnose chemistry
Antigens, Tumor-Associated, Carbohydrate immunology
Rhamnose immunology
Serum Albumin, Bovine immunology

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