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Adolescent Nonalcoholic Fatty Liver Disease and Type 2 Diabetes in Young Adulthood.
- Source :
-
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2021 Jan 01; Vol. 106 (1), pp. e34-e44. - Publication Year :
- 2021
-
Abstract
- Context: The long-term risk of type 2 diabetes in adolescents with nonalcoholic fatty liver disease (NAFLD) is unclear.<br />Objective: To assess type 2 diabetes risk among adolescents with NAFLD.<br />Design and Setting: A nationwide, population-based study of Israeli adolescents who were examined before military service during 1997-2011 and were followed until December 31, 2016.<br />Participants: A total of 1 025 796 normoglycemic adolescents were included.<br />Interventions: Biopsy or radiographic tests were prerequisite for NAFLD diagnosis. Data were linked to the Israeli National Diabetes Registry.<br />Main Outcome Measures: Type 2 diabetes incidence.<br />Results: During a mean follow-up of 13.3 years, 12 of 633 adolescents with NAFLD (1.9%; all with high body mass index [BMI] at baseline) were diagnosed with type 2 diabetes compared with 2917 (0.3%) adolescents without NAFLD. The hazard ratio (HR) for type 2 diabetes was 2.59 (95% confidence interval [CI], 1.47-4.58) for the NAFLD vs. the non-NAFLD group after adjustment for BMI and sociodemographic confounders. The elevated risk persisted in several sensitivity analyses. These included an analysis of persons without other metabolic comorbidities (adjusted HR, 2.75 [95% CI, 1.48-5.14]) and of persons with high BMI; and an analysis whose outcome was type 2 diabetes by age 30 years (adjusted HR, 2.14 [95% CI, 1.02-4.52]). The results remained significant when a sex-, birth year-, and BMI-matched control group was the reference (adjusted HR, 2.98 [95% CI, 1.54-5.74]).<br />Conclusions: Among normoglycemic adolescents, NAFLD was associated with an increased adjusted risk for type 2 diabetes, which may be apparent before age 30 years.<br /> (© The Author(s) 2020. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Subjects :
- Adolescent
Adult
Age of Onset
Body Mass Index
Case-Control Studies
Diabetes Mellitus, Type 2 etiology
Female
Follow-Up Studies
Humans
Incidence
Israel epidemiology
Male
Non-alcoholic Fatty Liver Disease complications
Risk Factors
Young Adult
Diabetes Mellitus, Type 2 epidemiology
Non-alcoholic Fatty Liver Disease epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1945-7197
- Volume :
- 106
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Journal of clinical endocrinology and metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 33075820
- Full Text :
- https://doi.org/10.1210/clinem/dgaa753