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Cu-Catalyzed Regioselective C-H Alkylation of Benzimidazoles with Aromatic Alkenes.
- Source :
-
Organic letters [Org Lett] 2020 Nov 06; Vol. 22 (21), pp. 8250-8255. Date of Electronic Publication: 2020 Oct 19. - Publication Year :
- 2020
-
Abstract
- Herein we report a novel Cu-catalyzed regioselective C2-H alkylation of benzimidazoles with aromatic alkenes. The reaction features exclusive regioselectivity and broad substrate scope in the intermolecular alkylation of benzimidazoles with terminal and internal aromatic alkenes, constituting a modular access toward benzimidazole-containing 1,1-di(hetero)aryl alkanes. The intramolecular C2-H alkylation of benzimidazoles with aromatic alkenes has been achieved in an endo -selective manner. The enantioselective C2 alkylation of benzimidazoles has also been realized with moderate to good stereocontrol.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 22
- Issue :
- 21
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 33075228
- Full Text :
- https://doi.org/10.1021/acs.orglett.0c02864