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Association of TG/HDLC ratio trajectory and risk of type 2 diabetes: A retrospective cohort study in China.
- Source :
-
Journal of diabetes [J Diabetes] 2020 Oct 19. Date of Electronic Publication: 2020 Oct 19. - Publication Year :
- 2020
- Publisher :
- Ahead of Print
-
Abstract
- Background: The association of ratio of triglycerides to high-density lipoprotein cholesterol (TG/HDL-C ratio) change trajectory with risk of type 2 diabetes mellitus (T2DM) remains unknown. The aim of this study was to evaluate the association between risk of T2DM and TG/HDL-C ratio change trajectory.<br />Methods: A total of 18 444 participants aged 18-80 years old were included in this cohort study. Linear regression and quadratic regression models were used to determine the TG/HDL-C ratio change trajectory. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between TG/HDL-C ratio change trajectory and probability of T2DM.<br />Results: T2DM developed in 714 participants during a median follow-up of 5.74 years (92 076.23 person-years of follow-up). After adjusting for baseline potential confounders, odds of T2DM were greater for participants with the increasing, U-shape, bell-shape, and other shape change vs decreasing change (adjusted OR [aOR] 2.01, 95% CI 1.42-2.81; 1.56, 1.15-2.13; 1.60, 1.17-2.20; and 1.49, 1.13-2.00, respectively). The results were robust in the sensitivity analyses on excluding baseline participants with T2DM. Moreover, the associations remained significant with male sex, age <60 years and body mass index <24 kg/m <superscript>2</superscript> .<br />Conclusions: This retrospective study revealed increased probability of T2DM with increasing, U-shape, bell-shape, and other-shape TG/HDL-C ratio change trajectories, especially with male sex, age <60 years and body mass index <24 kg/m <superscript>2</superscript> .<br /> (© 2020 Ruijin Hospital, Shanghai JiaoTong University School of Medicine and John Wiley & Sons Australia, Ltd.)
Details
- Language :
- English
- ISSN :
- 1753-0407
- Database :
- MEDLINE
- Journal :
- Journal of diabetes
- Publication Type :
- Academic Journal
- Accession number :
- 33074586
- Full Text :
- https://doi.org/10.1111/1753-0407.13123