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Markers of Endothelial Cells in Normal and Pathological Conditions.

Authors :
Goncharov NV
Popova PI
Avdonin PP
Kudryavtsev IV
Serebryakova MK
Korf EA
Avdonin PV
Source :
Biochemistry (Moscow) Supplement. Series A, Membrane and cell biology [Biochem (Mosc) Suppl Ser A Membr Cell Biol] 2020; Vol. 14 (3), pp. 167-183. Date of Electronic Publication: 2020 Oct 13.
Publication Year :
2020

Abstract

Endothelial cells (ECs) line the blood vessels and lymphatic vessels, as well as heart chambers, forming the border between the tissues, on the one hand, and blood or lymph, on the other. Such a strategic position of the endothelium determines its most important functional role in the regulation of vascular tone, hemostasis, and inflammatory processes. The damaged endothelium can be both a cause and a consequence of many diseases. The state of the endothelium is indicated by the phenotype of these cells, represented mainly by (trans)membrane markers (surface antigens). This review defines endothelial markers, provides a list of them, and considers the mechanisms of their expression and the role of the endothelium in certain pathological conditions.<br />Competing Interests: The authors declare that they have no conflict of interest.<br /> (© Pleiades Publishing, Ltd. 2020.)

Details

Language :
English
ISSN :
1990-7478
Volume :
14
Issue :
3
Database :
MEDLINE
Journal :
Biochemistry (Moscow) Supplement. Series A, Membrane and cell biology
Publication Type :
Academic Journal
Accession number :
33072245
Full Text :
https://doi.org/10.1134/S1990747819030140