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Obtaining EQ-5D-5L utilities from the disease specific quality of life Alzheimer's disease scale: development and results from a mapping study.
- Source :
-
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation [Qual Life Res] 2021 Mar; Vol. 30 (3), pp. 867-879. Date of Electronic Publication: 2020 Oct 17. - Publication Year :
- 2021
-
Abstract
- Purpose: The Quality of Life Alzheimer's Disease Scale (QoL-AD) is commonly used to assess disease specific health-related quality of life (HRQoL) as rated by patients and their carers. For cost-effectiveness analyses, utilities based on the EQ-5D are often required. We report a new mapping algorithm to obtain EQ-5D indices when only QoL-AD data are available.<br />Methods: Different statistical models to estimate utility directly, or responses to individual EQ-5D questions (response mapping) from QoL-AD, were trialled for patient-rated and proxy-rated questionnaires. Model performance was assessed by root mean square error and mean absolute error.<br />Results: The response model using multinomial regression including age and sex, performed best in both the estimation dataset and an independent dataset.<br />Conclusions: The recommended mapping algorithm allows researchers for the first time to estimate EQ-5D values from QoL-AD data, enabling cost-utility analyses using datasets where the QoL-AD but no utility measures were collected.
Details
- Language :
- English
- ISSN :
- 1573-2649
- Volume :
- 30
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
- Publication Type :
- Academic Journal
- Accession number :
- 33068236
- Full Text :
- https://doi.org/10.1007/s11136-020-02670-8