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Characterization of the intestinal microbiota during Citrobacter rodentium infection in a mouse model of infection-triggered Parkinson's disease.

Authors :
Cannon T
Sinha A
Trudeau LE
Maurice CF
Gruenheid S
Source :
Gut microbes [Gut Microbes] 2020 Nov 09; Vol. 12 (1), pp. 1-11.
Publication Year :
2020

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder that has been shown to be influenced by the intestinal milieu. The gut microbiota is altered in PD patients, and murine studies have begun suggesting a causative role for the gut microbiota in progression of PD. We have previously shown that repeated infection with the intestinal murine pathogen Citrobacter rodentium resulted in the development of PD-like pathology in Pink1 <superscript>-/-</superscript> mice compared to wild-type littermates. This addendum aims to expand this work by characterizing the gut microbiota during C. rodentium infection in our Pink1 <superscript>-/-</superscript> PD model. We observed little disturbance to the fecal microbiota diversity both between infection timepoints and between Pink1 <superscript>-/-</superscript> and wild-type control littermates. However, the level of short-chain fatty acids appeared to be altered over the course of infection with butyric acid significantly increasing in Pink1 <superscript>-/-</superscript> mice and isobutyric acid increasing in wild-type mice.

Details

Language :
English
ISSN :
1949-0984
Volume :
12
Issue :
1
Database :
MEDLINE
Journal :
Gut microbes
Publication Type :
Academic Journal
Accession number :
33064969
Full Text :
https://doi.org/10.1080/19490976.2020.1830694