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Characterization of the intestinal microbiota during Citrobacter rodentium infection in a mouse model of infection-triggered Parkinson's disease.
- Source :
-
Gut microbes [Gut Microbes] 2020 Nov 09; Vol. 12 (1), pp. 1-11. - Publication Year :
- 2020
-
Abstract
- Parkinson's disease (PD) is a neurodegenerative disorder that has been shown to be influenced by the intestinal milieu. The gut microbiota is altered in PD patients, and murine studies have begun suggesting a causative role for the gut microbiota in progression of PD. We have previously shown that repeated infection with the intestinal murine pathogen Citrobacter rodentium resulted in the development of PD-like pathology in Pink1 <superscript>-/-</superscript> mice compared to wild-type littermates. This addendum aims to expand this work by characterizing the gut microbiota during C. rodentium infection in our Pink1 <superscript>-/-</superscript> PD model. We observed little disturbance to the fecal microbiota diversity both between infection timepoints and between Pink1 <superscript>-/-</superscript> and wild-type control littermates. However, the level of short-chain fatty acids appeared to be altered over the course of infection with butyric acid significantly increasing in Pink1 <superscript>-/-</superscript> mice and isobutyric acid increasing in wild-type mice.
- Subjects :
- Animals
Bacteria classification
Bacteria growth & development
Disease Models, Animal
Fatty Acids, Volatile analysis
Fatty Acids, Volatile metabolism
Feces chemistry
Feces microbiology
Mice
Protein Kinases genetics
Citrobacter rodentium physiology
Enterobacteriaceae Infections microbiology
Gastrointestinal Microbiome
Parkinson Disease microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1949-0984
- Volume :
- 12
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Gut microbes
- Publication Type :
- Academic Journal
- Accession number :
- 33064969
- Full Text :
- https://doi.org/10.1080/19490976.2020.1830694