Advances in the Study of the Potential Hepatotoxic Components and Mechanism of Polygonum multiflorum .

Authors :: Yu HS
Wang LL
He Y
Han LF
Ding H
Song XB
Gao XM
Yun NR
Li Z
Source :: Evidence-based complementary and alternative medicine : eCAM [Evid Based Complement Alternat Med] 2020 Sep 30; Vol. 2020, pp. 6489648. Date of Electronic Publication: 2020 Sep 30 (Print Publication: 2020).
Publication Year :: 2020
Abstract: The roots of Polygonum multiflorum (PM) (He Shou Wu in Chinese) are one of the most commonly used tonic traditional Chinese medicines (TCMs) in China. PM is traditionally valued for its antiaging, liver- and kidney-tonifying, and hair-blackening effects. However, an increasing number of hepatotoxicity cases induced by PM attract the attention of scholars worldwide. Thus far, the potential liver injury compounds and the mechanism are still uncertain. The aim of this review is to provide comprehensive information on the potential hepatotoxic components and mechanism of PM based on the scientific literature. Moreover, perspectives for future investigations of hepatotoxic components are discussed. This study will build a new foundation for further study on the hepatotoxic components and mechanism of PM.<br />Competing Interests: The authors declare that they have no conflicts of interest regarding the publication of this paper.<br /> (Copyright © 2020 He-Shui Yu et al.)

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