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The U Shaped Relationship Between High-Density Lipoprotein Cholesterol and All-Cause or Cause-Specific Mortality in Adult Population.
- Source :
-
Clinical interventions in aging [Clin Interv Aging] 2020 Oct 02; Vol. 15, pp. 1883-1896. Date of Electronic Publication: 2020 Oct 02 (Print Publication: 2020). - Publication Year :
- 2020
-
Abstract
- Purpose: The associations of high-density lipoprotein cholesterol (HDL-C) with mortality are still unclear. We explored the associations of HDL-C with all-cause and cause-specific mortality in an adult population.<br />Methods: Deaths were classified into all-cause, cardiovascular, and cancer mortality. Survival curve, multivariate Cox regression, and subgroup analyses were conducted, and hazard ratio (HR) and 95% confidence interval (CI) were performed. We fitted Cox regression models for all-cause, cardiovascular, and cancer mortality to evaluate their associations with categories of HDL-C (≤30, 31-40, 41-50, 51-60 [reference], 61-70, >70 mg/dL).<br />Results: A total of 42,145 (20,415 (48.44%) males, mean age 47.12±19.40 years) subjects were enrolled. At an average follow-up of 97.52±54.03 months, all-cause, cardiovascular, and cancer mortality numbers were 5,061 (12.01), 1,081 (2.56%), and 1,061 (2.52%), respectively. When compared with the reference group (HDL-C: 51-60 mg/dL), a U-shaped association was apparent for all-cause mortality, with elevated risk in participants with the lowest (≤30 mg/dL) (HR=1.33; 95% CI=1.14- 1.56) and highest (>70 mg/dL) (HR=1.14; 95% CI=1.02-1.27) HDL-C concentration. Associations for cardiovascular and cancer mortality were non-linear. An elevated risk for cancer mortality was observed in those with the highest HDL-C concentration (HR=1.06; 95% CI-0.84-1.34) compared with the reference group, although it was not statistically significant. The effect of HDL-C on mortality was adjusted by some traditional risk factors including age, gender, race, or comorbidities.<br />Conclusion: A U-shaped association was observed between HDL-C and all-cause mortality among an adult population.<br />Competing Interests: The authors of this paper reported no financial conflicts of interest.<br /> (© 2020 Huang et al.)
Details
- Language :
- English
- ISSN :
- 1178-1998
- Volume :
- 15
- Database :
- MEDLINE
- Journal :
- Clinical interventions in aging
- Publication Type :
- Academic Journal
- Accession number :
- 33061337
- Full Text :
- https://doi.org/10.2147/CIA.S271528