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NK Cell-mediated Neuroblastoma Cell Lysis is Enhanced by IgG From Patients With Pediatric Opsoclonus-Myoclonus Syndrome.
- Source :
-
Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2021 Mar 01; Vol. 43 (2), pp. e176-e179. - Publication Year :
- 2021
-
Abstract
- Pediatric opsoclonus-myoclonussyndrome (OMS) is a rare autoimmune disorder of which 50% are associated with neuroblastoma (NB). We investigated whether surface-binding autoantibodies in OMS can enhance natural killer (NK) cell-mediated cytotoxicity in these patients. OMS immunoglobulin G (IgG) bound to NB cell lines and NK cell-mediated cytotoxicity to NB cells was enhanced after preincubation with OMS-IgG, but not IgG from NB without OMS or healthy controls. Activation of NK cells by surface-binding autoantibodies may be an additional mechanism of antitumor immunity in children with NB and OMS.<br />Competing Interests: The authors declare no conflict of interest.<br /> (Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.)
- Subjects :
- Autoantibodies blood
Autoantibodies drug effects
Child, Preschool
Female
Follow-Up Studies
Humans
Immunoglobulin G immunology
Infant
Killer Cells, Natural immunology
Male
Neuroblastoma blood
Neuroblastoma complications
Neuroblastoma immunology
Opsoclonus-Myoclonus Syndrome blood
Opsoclonus-Myoclonus Syndrome complications
Opsoclonus-Myoclonus Syndrome immunology
Prognosis
Apoptosis
Autoantibodies immunology
Immunoglobulin G adverse effects
Killer Cells, Natural pathology
Neuroblastoma pathology
Opsoclonus-Myoclonus Syndrome pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1536-3678
- Volume :
- 43
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of pediatric hematology/oncology
- Publication Type :
- Academic Journal
- Accession number :
- 33060390
- Full Text :
- https://doi.org/10.1097/MPH.0000000000001953