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Biomarkers for the toxicity of sublethal concentrations of triclosan to the early life stages of carps.
- Source :
-
Scientific reports [Sci Rep] 2020 Oct 14; Vol. 10 (1), pp. 17322. Date of Electronic Publication: 2020 Oct 14. - Publication Year :
- 2020
-
Abstract
- Accumulation, contents of protein, non-enzymatic antioxidant glutathione (GSH and GSSG), lipid peroxidation product (melondialdehyde-MDA) and organic acids (fumarate, succinate, malate and citrate), and activities of neurological (acetylcholinesterase-AChE), detoxification (glutathione S-transferase-GST) and metabolic (lactate dehydrogenase-LDH, aspartate transaminase-AST and alanine transaminase-ALT) enzymes were recorded in the hatchlings of Cyprinus carpio, Ctenopharyngodon idella, Labeo rohita and Cirrhinus mrigala after 7 and 14 days exposure and 10 days post exposure (recovery period) to sublethal concentrations (0.005, 0.01, 0.02 and 0.05 mg/L) of triclosan, a highly toxic and persistent biocide used in personal care products. Accumulation was maximum between 7-14 days at 0.01 mg/L for C. carpio and L. rohita but at 0.005 mg/L for C. idella and C. mrigala. No triclosan was observed at 0.005 mg/L in C. carpio and C. mrigala after recovery. Significant decline in protein, glutathione and acetylcholinesterase but increase in glutathione S-transferase, lactate dehydrogenase, aspartate transaminase, alanine transaminase, melondialdehyde and organic acids over control during exposure continued till the end of recovery period. Integrated biomarker response (IBR) analysis depicted higher star plot area for glutathione and glutathione S-transferase during initial 7 days of exposure, thereafter, during 7-14 days of exposure and the recovery period, higher star plot area was observed for acetylcholinesterase, aspartate transaminase, alanine transaminase and organic acids. Higher star plot area was observed for protein in all the species throughout the study. The study shows that L. rohita is most sensitive and glutathione, acetylcholinesterase, aspartate transaminase and alanine transaminase are the biomarkers for the toxicity of sublethal concentrations of TCS.
- Subjects :
- Animals
Anti-Infective Agents, Local administration & dosage
Anti-Infective Agents, Local pharmacokinetics
Carps metabolism
Citric Acid analysis
Cosmetics chemistry
Dicarboxylic Acids analysis
Dose-Response Relationship, Drug
Enzymes analysis
Glutathione analysis
Glutathione Disulfide analysis
Malondialdehyde analysis
Oxidants administration & dosage
Oxidants pharmacokinetics
Proteins analysis
Species Specificity
Triclosan administration & dosage
Triclosan pharmacokinetics
Water Pollutants, Chemical administration & dosage
Water Pollutants, Chemical pharmacokinetics
Anti-Infective Agents, Local toxicity
Biomarkers analysis
Carps growth & development
Oxidants toxicity
Triclosan toxicity
Water Pollutants, Chemical toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 33057045
- Full Text :
- https://doi.org/10.1038/s41598-020-73042-y