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Prognostic value of plasma big endothelin-1 in left ventricular non-compaction cardiomyopathy.
- Source :
-
Heart (British Cardiac Society) [Heart] 2021 May; Vol. 107 (10), pp. 836-841. Date of Electronic Publication: 2020 Oct 14. - Publication Year :
- 2021
-
Abstract
- Objective: To determine the prognostic role of big endothelin-1 (ET-1) in left ventricular non-compaction cardiomyopathy (LVNC).<br />Methods: We prospectively enrolled patients whose LVNC was diagnosed by cardiac MRI and who had big ET-1 data available. Primary end point was a composite of all-cause mortality, heart transplantation, sustained ventricular tachycardia/fibrillation and implanted cardioverter defibrillator discharge. Secondary end point was cardiac death or heart transplantation.<br />Results: Altogether, 203 patients (median age 44 years; 70.9% male) were divided into high-level (≥0.42 pmol/L) and low-level (<0.42 pmol/L) big ET-1 groups according to the median value of plasma big ET-1 levels. Ln big ET-1 was positively associated with Ln N-terminal pro-brain natriuretic peptide, left ventricular diameter, but negatively related to age and Ln left ventricular ejection fraction. Median follow-up was 1.9 years (IQR 0.9-3.1 years). Kaplan-Meier analysis showed that, compared with patients with low levels of big ET-1, those with high levels were at greater risk for meeting both primary (p<0.001) and secondary (p<0.001) end points. The C-statistic estimation of Ln big ET-1 for predicting the primary outcome was 0.755 (95% CI 0.685 to 0.824, p<0.001). After adjusting for confounding factors, Ln big ET-1 was identified as an independent predictor of the composite primary outcome (HR 1.83, 95% CI 1.27 to 2.62, p=0.001) and secondary outcome (HR 1.93, 95% CI 1.32 to 2.83, p=0.001).<br />Conclusions: Plasma big ET-1 may be a valuable index to predict the clinical adverse outcomes in patients with LVNC.<br />Competing Interests: Competing interests: None declared.<br /> (© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
- Subjects :
- Adult
Biomarkers blood
Death, Sudden, Cardiac epidemiology
Defibrillators, Implantable statistics & numerical data
Female
Heart Transplantation statistics & numerical data
Heart Ventricles diagnostic imaging
Humans
Isolated Noncompaction of the Ventricular Myocardium therapy
Magnetic Resonance Imaging, Cine
Male
Middle Aged
Natriuretic Peptide, Brain blood
Peptide Fragments blood
Prognosis
Prospective Studies
Stroke Volume
Tachycardia, Ventricular epidemiology
Ventricular Fibrillation epidemiology
Endothelin-1 blood
Isolated Noncompaction of the Ventricular Myocardium complications
Isolated Noncompaction of the Ventricular Myocardium mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1468-201X
- Volume :
- 107
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Heart (British Cardiac Society)
- Publication Type :
- Academic Journal
- Accession number :
- 33055147
- Full Text :
- https://doi.org/10.1136/heartjnl-2020-317059