Back to Search
Start Over
The motivational valence of methamphetamine relates inversely to subsequent methamphetamine self-administration in female C57BL/6J mice.
- Source :
-
Behavioural brain research [Behav Brain Res] 2021 Feb 01; Vol. 398, pp. 112959. Date of Electronic Publication: 2020 Oct 11. - Publication Year :
- 2021
-
Abstract
- Understanding the mechanisms underpinning individual variance in addiction vulnerability requires the development of validated, high-throughput screens. In a prior study of a large sample of male isogenic C57BL/6J mice, the direction and magnitude of methamphetamine (MA)-induced place-conditioning predicts the propensity to acquire oral MA self-administration, as well as the efficacy of MA to serve as a reinforcer. The present study examined whether or not such a predictive relationship also exists in females. Adult C57BL/6J females underwent a 4-day MA place-conditioning paradigm (once daily injections of 2 mg/kg) and were then trained to nose-poke for delivery of a 20 mg/L MA solution under increasing schedules of reinforcement, followed by dose-response testing (5-400 mg/L MA). Akin to males, 53 % of the females exhibited a conditioned place-preference, while 32 % of the mice were MA-neutral and 15 % exhibited a conditioned place-aversion. However, unlike males, the place-conditioning phenotype did not transfer to MA-reinforced nose-poking behavior under operant-conditioning procedures, with 400 mg/L MA intake being inversely correlated place-conditioning. While only one MA-conditioning dose has been assayed to date, these data indicate that sex does not significantly shift the proportion of C57BL/6J mice that perceive MA's interoceptive effects as positive, neutral or aversive. However, a sex difference appears to exist regarding the predictive relationship between the motivational valence of MA and subsequent drug-taking behavior; females exhibit MA-taking behavior and reinforcement, despite their initial perception of the stimulant interoceptive effects as positive, neutral or negative.<br /> (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Behavior, Animal drug effects
Central Nervous System Stimulants administration & dosage
Disease Models, Animal
Female
Methamphetamine administration & dosage
Mice
Mice, Inbred C57BL
Sex Characteristics
Amphetamine-Related Disorders physiopathology
Central Nervous System Stimulants pharmacology
Conditioning, Classical drug effects
Conditioning, Operant drug effects
Methamphetamine pharmacology
Motivation drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7549
- Volume :
- 398
- Database :
- MEDLINE
- Journal :
- Behavioural brain research
- Publication Type :
- Academic Journal
- Accession number :
- 33053382
- Full Text :
- https://doi.org/10.1016/j.bbr.2020.112959