Antifungal Susceptibility Does Not Correlate With Fungal Clearance or Survival in AIDS-Associated Cryptococcal Meningitis.

Authors :: O'Connor L
Van Anh D
Chau TTH
Chau NVV
Huong LNP
Wolbers M
Day JN
Source :: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2021 Oct 05; Vol. 73 (7), pp. e2338-e2341.
Publication Year :: 2021
Abstract: We investigated the value of susceptibility testing in predicting response in AIDS-associated cryptococcal meningitis using clinical isolates from a randomized controlled trial of antifungal treatment (amphotericin monotherapy, amphotericin with flucytosine, or amphotericin with fluconazole). We found no correlation between antifungal susceptibility and either early or late survival, or fungal clearance.<br /> (© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.)

Subjects :: Antifungal Agents pharmacology
Antifungal Agents therapeutic use
Fluconazole pharmacology
Fluconazole therapeutic use
Flucytosine therapeutic use
Humans
Acquired Immunodeficiency Syndrome complications
Acquired Immunodeficiency Syndrome drug therapy
Meningitis, Cryptococcal drug therapy

Language :: English
ISSN :: 1537-6591
Volume :: 73
Issue :: 7
Database :: MEDLINE
Journal :: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Publication Type :: Academic Journal
Accession number :: 33051650
Full Text :: https://doi.org/10.1093/cid/ciaa1544

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