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Current treatment paradigms and emerging therapies for NAFLD/NASH.
- Source :
-
Frontiers in bioscience (Landmark edition) [Front Biosci (Landmark Ed)] 2021 Jan 01; Vol. 26 (2), pp. 206-237. Date of Electronic Publication: 2021 Jan 01. - Publication Year :
- 2021
-
Abstract
- Non-alcoholic fatty liver disease (NAFLD) is one the fastest emerging manifestations of the metabolic syndrome worldwide. Non-alcoholic steatohepatitis (NASH), the progressive form of NAFLD, may culminate into cirrhosis and hepatocellular cancer (HCC) and is presently a leading cause of liver transplant. Although a steady progress is seen in understanding of the disease epidemiology, pathogenesis and identifying therapeutic targets, the slowest advancement is seen in the therapeutic field. Currently, there is no FDA approved therapy for this disease and appropriate therapeutic targets are urgently warranted. In this review we discuss the role of lifestyle intervention, pharmacological agents, surgical approaches, and gut microbiome, with regard to therapy for NASH. In particular, we focus the role of insulin sensitizers, thyroid hormone mimetics, antioxidants, cholesterol lowering drugs, incretins and cytokines as therapeutic targets for NASH. We highlight these targets aiming to optimize the future for NASH therapy.
- Subjects :
- Carcinoma, Hepatocellular pathology
Disease Progression
Gastrointestinal Microbiome
Humans
Life Style
Liver Cirrhosis pathology
Liver Neoplasms pathology
Non-alcoholic Fatty Liver Disease drug therapy
Non-alcoholic Fatty Liver Disease pathology
Non-alcoholic Fatty Liver Disease surgery
Non-alcoholic Fatty Liver Disease therapy
Subjects
Details
- Language :
- English
- ISSN :
- 2768-6698
- Volume :
- 26
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Frontiers in bioscience (Landmark edition)
- Publication Type :
- Academic Journal
- Accession number :
- 33049668
- Full Text :
- https://doi.org/10.2741/4892