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DNA Self-Assembly Mediated by Programmable Soft-Patchy Interactions.
- Source :
-
ACS nano [ACS Nano] 2020 Oct 27; Vol. 14 (10), pp. 13524-13535. Date of Electronic Publication: 2020 Oct 13. - Publication Year :
- 2020
-
Abstract
- Adding shape and interaction anisotropy to a colloidal particle offers exquisitely tunable routes to engineer a rich assortment of complex-architected structures. Inspired by the hierarchical self-assembly concept with block copolymers and DNA liquid crystals and exploiting the unique assembly properties of DNA, we report here the construction and self-assembly of DNA-based soft-patchy anisotropic particles with a high degree of modularity in the system's design. By programmable positioning of thermoresponsive polymeric patches on the backbone of a stiff DNA duplex with linear and star-shaped architecture, we reversibly drive the DNA from a disordered ensemble to a diverse array of long-range ordered multidimensional nanostructures with tunable lattice spacing, ranging from lamellar to bicontinuous double-gyroid and double-diamond cubic morphologies, through the alteration of temperature. Our results demonstrate that the proposed hierarchical self-assembly strategy can be applied to any kind of DNA nanoarchitecture, highlighting the design principles for integration of self-assembly concepts from the physics of liquid crystals, block copolymers, and patchy colloids into the continuously growing interdisciplinary research field of structural DNA nanotechnology.
- Subjects :
- Anisotropy
DNA
Nanotechnology
Colloids
Nanostructures
Subjects
Details
- Language :
- English
- ISSN :
- 1936-086X
- Volume :
- 14
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- ACS nano
- Publication Type :
- Academic Journal
- Accession number :
- 33048544
- Full Text :
- https://doi.org/10.1021/acsnano.0c05536