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Ketamine/Xylazine Anesthesia-Related Corneal Lesions in Rats With Surgically Implanted Venous Catheters Utilized in Nonclinical Intravenous Studies.

Authors :
Zwick LS
Patrick DJ
Knupp LC
Ramos MF
Source :
Toxicologic pathology [Toxicol Pathol] 2021 Apr; Vol. 49 (3), pp. 598-601. Date of Electronic Publication: 2020 Oct 12.
Publication Year :
2021

Abstract

Nonclinical rodent studies with repeat slow intravenous dosing, such as safety assessments of anticancer therapeutics, often require the use of animals with surgically implanted catheters. Catheterization is a relatively short surgical procedure but requires use of anesthesia. Ketamine/xylazine injectable anesthesia is typically used because it has advantages over inhalation anesthesia including ease of administration, safety and predictability of effects, and relatively low cost. However, ketamine/xylazine anesthesia in rodents can also be associated with the development of undesirable corneal lesions of uncertain mechanism such as mineralization of Bowman's membrane or stroma, erosion/ulceration, inflammation, fibroplasia, and neovascularization. Such findings have the potential to confound study interpretation in programs for which the cornea is a potential target tissue. This case report describes the occurrence of ketamine/xylazine-related corneal lesions observed in surgically catheterized rats in a 16-day toxicity study for an oncology compound.

Details

Language :
English
ISSN :
1533-1601
Volume :
49
Issue :
3
Database :
MEDLINE
Journal :
Toxicologic pathology
Publication Type :
Academic Journal
Accession number :
33043871
Full Text :
https://doi.org/10.1177/0192623320960705