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Systemic Reprogramming of Monocytes in Cancer.

Authors :
Kiss M
Caro AA
Raes G
Laoui D
Source :
Frontiers in oncology [Front Oncol] 2020 Sep 17; Vol. 10, pp. 1399. Date of Electronic Publication: 2020 Sep 17 (Print Publication: 2020).
Publication Year :
2020

Abstract

Monocytes influence multiple aspects of tumor progression, including antitumor immunity, angiogenesis, and metastasis, primarily by infiltrating tumors, and differentiating into tumor-associated macrophages. Emerging evidence suggests that the tumor-induced systemic environment influences the development and phenotype of monocytes before their arrival to the tumor site. As a result, circulating monocytes show functional alterations in cancer, such as the acquisition of immunosuppressive activity and reduced responsiveness to inflammatory stimuli. In this review, we summarize available evidence about cancer-induced changes in monopoiesis and its impact on the abundance and function of monocytes in the periphery. In addition, we describe the phenotypical alterations observed in tumor-educated peripheral blood monocytes and highlight crucial gaps in our knowledge about additional cellular functions that may be affected based on transcriptomic studies. We also highlight emerging therapeutic strategies that aim to reverse cancer-induced changes in monopoiesis and peripheral monocytes to inhibit tumor progression and improve therapy responses. Overall, we suggest that an in-depth understanding of systemic monocyte reprogramming will have implications for cancer immunotherapy and the development of clinical biomarkers.<br /> (Copyright © 2020 Kiss, Caro, Raes and Laoui.)

Details

Language :
English
ISSN :
2234-943X
Volume :
10
Database :
MEDLINE
Journal :
Frontiers in oncology
Publication Type :
Academic Journal
Accession number :
33042791
Full Text :
https://doi.org/10.3389/fonc.2020.01399