Probiotics, Prebiotics, Synbiotics, and Paraprobiotics as a Therapeutic Alternative for Intestinal Mucositis.

Authors :: Batista VL
da Silva TF
de Jesus LCL
Coelho-Rocha ND
Barroso FAL
Tavares LM
Azevedo V
Mancha-Agresti P
Drumond MM
Source :: Frontiers in microbiology [Front Microbiol] 2020 Sep 17; Vol. 11, pp. 544490. Date of Electronic Publication: 2020 Sep 17 (Print Publication: 2020).
Publication Year :: 2020
Abstract: Intestinal mucositis, a cytotoxic side effect of the antineoplastic drug 5-fluorouracil (5-FU), is characterized by ulceration, inflammation, diarrhea, and intense abdominal pain, making it an important issue for clinical medicine. Given the seriousness of the problem, therapeutic alternatives have been sought as a means to ameliorate, prevent, and treat this condition. Among the alternatives available to address this side effect of treatment with 5-FU, the most promising has been the use of probiotics, prebiotics, synbiotics, and paraprobiotics. This review addresses the administration of these "biotics" as a therapeutic alternative for intestinal mucositis caused by 5-FU. It describes the effects and benefits related to their use as well as their potential for patient care.<br /> (Copyright © 2020 Batista, da Silva, de Jesus, Coelho-Rocha, Barroso, Tavares, Azevedo, Mancha-Agresti and Drumond.)

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