Colocalization of tracks from boron neutron capture reactions and images of isolated cells.

Authors :: Postuma I
Sommi P
Vitali A
Shu D
Martino GD
Cansolino L
Ferrari C
Ricci V
Magni C
Protti N
Fatemi S
Tamburini UA
Bortolussi S
Altieri S
Source :: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine [Appl Radiat Isot] 2021 Jan; Vol. 167, pp. 109353. Date of Electronic Publication: 2020 Oct 04.
Publication Year :: 2021
Abstract: In Boron Neutron Capture Therapy, the boronated drug plays a leading role in delivering a lethal dose to the tumour. The effectiveness depends on the boron macroscopic concentration and on its distribution at sub-cellular level. This work shows a way to colocalize alpha particles and lithium ions tracks with cells. A neutron autoradiography technique is used, which combines images of cells with images of tracks produced in a solid-state nuclear track detector.<br /> (Copyright © 2020 Elsevier Ltd. All rights reserved.)

Subjects :: Autoradiography
Cell Line, Tumor
Dose-Response Relationship, Radiation
Humans
Boron Neutron Capture Therapy methods
Radiometry methods

Language :: English
ISSN :: 1872-9800
Volume :: 167
Database :: MEDLINE
Journal :: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
Publication Type :: Academic Journal
Accession number :: 33039761
Full Text :: https://doi.org/10.1016/j.apradiso.2020.109353

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