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Capsaicin up-regulates pro-apoptotic activity of thiazolidinediones in glioblastoma cell line.
- Source :
-
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2020 Dec; Vol. 132, pp. 110741. Date of Electronic Publication: 2020 Oct 07. - Publication Year :
- 2020
-
Abstract
- Capsaicin (N-vanillyl-8-methyl-alpha-nonenamide), a spicy, neurotoxic component of hot pepper is a ligand of vanilloid type-I (TRPV1) receptor of anti-cancer potential. However, molecular mechanism of its action is not fully understood. We found that capsaicin stimulated intrinsic and extrinsic pathway of apoptosis in human glioblastoma LN-18 cell line and this phenomenon was not dependent on TRPV1. Activation of peroxisome proliferator-activated receptor gamma (PPARγ), a ligand-dependent transcription factor, also induced apoptosis in glioblastoma cells. Although PPARγ ligands (thiazolidinediones - rosiglitazone, pioglitazone) promoted apoptosis in LN-18 cells, capsaicin augmented this effect. We found that capsaicin in a dose dependent manner induced expression of PPARγ in glioblastoma LN-18 cells. These findings suggest that capsaicin-dependent up-regulation of PPARγ represent the mechanism for augmentation of cell death by thiazolidinediones.<br /> (Copyright © 2020 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
- Subjects :
- Brain Neoplasms drug therapy
Brain Neoplasms pathology
Capsaicin administration & dosage
Cell Line, Tumor
Dose-Response Relationship, Drug
Drug Synergism
Glioblastoma pathology
Humans
Ligands
PPAR gamma metabolism
Pioglitazone administration & dosage
Rosiglitazone administration & dosage
TRPV Cation Channels metabolism
Up-Regulation drug effects
Apoptosis drug effects
Capsaicin pharmacology
Glioblastoma drug therapy
Pioglitazone pharmacology
Rosiglitazone pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1950-6007
- Volume :
- 132
- Database :
- MEDLINE
- Journal :
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- Publication Type :
- Academic Journal
- Accession number :
- 33038582
- Full Text :
- https://doi.org/10.1016/j.biopha.2020.110741