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Non-canonical roles of NAMPT and PARP in inflammation.

Authors :
Martínez-Morcillo FJ
Cantón-Sandoval J
Martínez-Menchón T
Corbalán-Vélez R
Mesa-Del-Castillo P
Pérez-Oliva AB
García-Moreno D
Mulero V
Source :
Developmental and comparative immunology [Dev Comp Immunol] 2021 Feb; Vol. 115, pp. 103881. Date of Electronic Publication: 2020 Oct 07.
Publication Year :
2021

Abstract

Nicotinamide adenine dinucleotide (NAD <superscript>+</superscript> ) is the most important hydrogen carrier in cell redox reactions. It is involved in mitochondrial function and metabolism, circadian rhythm, the immune response and inflammation, DNA repair, cell division, protein-protein signaling, chromatin remodeling and epigenetics. Recently, NAD <superscript>+</superscript> has been recognized as the molecule of life, since, by increasing NAD <superscript>+</superscript> levels in old or sick animals, it is possible to improve their health and lengthen their lifespan. In this review, we summarize the contribution of NAD <superscript>+</superscript> metabolism to inflammation, with special emphasis in the major NAD <superscript>+</superscript> biosynthetic enzyme, nicotinamide phosphoribosyl transferase (NAMPT), and the NAD <superscript>+</superscript> -consuming enzyme, poly(ADP-ribose) polymerase (PARP). The extracurricular roles of these enzymes, i.e. the proinflammatory role of NAMPT after its release, and the ability of PARP to promote a novel form of cell death, known as parthanatos, upon hyperactivation are revised and discussed in the context of several chronic inflammatory diseases.<br /> (Copyright © 2020 Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1879-0089
Volume :
115
Database :
MEDLINE
Journal :
Developmental and comparative immunology
Publication Type :
Academic Journal
Accession number :
33038343
Full Text :
https://doi.org/10.1016/j.dci.2020.103881