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Pathophysiology of high fat diet induced obesity: impact of probiotic banana juice on obesity associated complications and hepatosteatosis.
- Source :
-
Scientific reports [Sci Rep] 2020 Oct 09; Vol. 10 (1), pp. 16894. Date of Electronic Publication: 2020 Oct 09. - Publication Year :
- 2020
-
Abstract
- The high fat diet alters intestinal microbiota due to increased intestinal permeability and susceptibility to microbial antigens leads to metabolic endotoxemia. But probiotic juices reported for various health benefits. In this background we hypothesized that pectinase treated probiotic banana juice has diverse effects on HFD induced obesity and non-alcoholic steatohepatitis. 20 weeks fed HFD successfully induced obesity and its associated complications in experimental rats. The supplementation of probiotic banana juice for 5 months at a dose of 5 mL/kg bw/day resulted significant decrease (p < 0.05) in body weight (380 ± 0.34), total fat (72 ± 0.8), fat percentage (17 ± 0.07) and fat free mass (165 ± 0.02). Reduction (p < 0.05) in insulin resistance (5.20 ± 0.03), lipid profile (TC 120 ± 0.05; TG 160 ± 0.24; HDL 38 ± 0.03), liver lipid peroxidation (0.7 ± 0.01), hepatic enzyme markers (AST 82 ± 0.06; ALT 78 ± 0.34; ALP 42 ± 0.22), and hepatic steatosis by increasing liver antioxidant potential (CAT 1.4 ± 0.30; GSH 1.04 ± 0.04; SOD 0.82 ± 0.22) with normal hepatic triglycerides (15 ± 0.02) and glycogen (0.022 ± 0.15) contents and also showed normal liver size, less accumulation of lipid droplets with only a few congestion. It is concluded that the increased intestinal S. cerevisiae yeast can switch anti-obesity, antidiabetic, antioxidative stress, antioxidant and anti-hepatosteatosis effect. This study results will have significant implications for treatment of NAFLD.
- Subjects :
- Animals
Antioxidants metabolism
Body Weight drug effects
Fatty Liver metabolism
Fruit and Vegetable Juices
Insulin Resistance physiology
Lipid Metabolism drug effects
Lipid Peroxidation drug effects
Lipids
Liver drug effects
Liver metabolism
Male
Non-alcoholic Fatty Liver Disease drug therapy
Non-alcoholic Fatty Liver Disease metabolism
Obesity metabolism
Oxidative Stress drug effects
Rats
Rats, Wistar
Saccharomyces cerevisiae drug effects
Triglycerides metabolism
Diet, High-Fat adverse effects
Fatty Liver drug therapy
Musa metabolism
Obesity drug therapy
Probiotics pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 33037249
- Full Text :
- https://doi.org/10.1038/s41598-020-73670-4