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Serum IL-36 cytokines levels in type 2 diabetes mellitus patients and their association with obesity, insulin resistance, and inflammation.
- Source :
-
Journal of clinical laboratory analysis [J Clin Lab Anal] 2021 Feb; Vol. 35 (2), pp. e23611. Date of Electronic Publication: 2020 Oct 09. - Publication Year :
- 2021
-
Abstract
- Background: The interleukin (IL)-36 cytokines include IL-36α, IL-36β, IL-36γ, and IL-36Ra. Little was known about their roles in type 2 diabetes mellitus (T2DM).<br />Methods: The study included 40 T2DM patients and 42 healthy control subjects. The anthropometric and biochemical measurements were performed using automatic biochemical analyzer, high-performance liquid chromatography, and electrochemiluminescence immunoassay. Circulating IL-36α, IL-36γ, IL-36Ra, and IL-17 levels were determined by enzyme-linked immunosorbent assay.<br />Results: Serum IL-36α, IL-36γ, and IL-17 levels in T2DM patients were significantly higher than those in controls, whereas serum IL-36Ra levels in T2DM patients were lower. Correlation analysis showed that serum IL-36α was positively correlated with high sensitivity C-reactive protein. Serum IL-36α was negatively correlated with IL-36Ra. Serum IL-17 was negatively correlated with low-density lipoprotein cholesterol.<br />Conclusions: This study demonstrated that T2DM patients displayed increased IL-36α and IL-36γ expression and decreased IL-36Ra expression. Moreover, the inflammatory cytokine levels were directly proportional to the inflammation and blood lipid levels. Our results suggest that IL-36 cytokines may be a new target for the diagnosis or treatment of T2DM.<br /> (© 2020 The Authors. Journal of Clinical Laboratory Analysis Published by Wiley Periodicals LLC.)
Details
- Language :
- English
- ISSN :
- 1098-2825
- Volume :
- 35
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of clinical laboratory analysis
- Publication Type :
- Academic Journal
- Accession number :
- 33034926
- Full Text :
- https://doi.org/10.1002/jcla.23611