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Genomics of Ocular Chlamydia trachomatis After 5 Years of SAFE Interventions for Trachoma in Amhara, Ethiopia.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2022 Mar 15; Vol. 225 (6), pp. 994-1004. - Publication Year :
- 2022
-
Abstract
- Background: To eliminate trachoma as a public health problem, the World Health Organization recommends the SAFE (surgery, antibiotics, facial cleanliness, and environmental improvement) strategy. As part of the SAFE strategy in the Amhara Region, Ethiopia, the Trachoma Control Program distributed >124 million doses of antibiotics between 2007 and 2015. Despite this, trachoma remained hyperendemic in many districts and a considerable level of Chlamydia trachomatis (Ct) infection was evident.<br />Methods: We utilized residual material from Abbott m2000 Ct diagnostic tests to sequence 99 ocular Ct samples from Amhara and investigated the role of Ct genomic variation in continued transmission of Ct.<br />Results: Sequences were typical of ocular Ct at the whole-genome level and in tissue tropism-associated genes. There was no evidence of macrolide resistance in this population. Polymorphism around the ompA gene was associated with village-level trachomatous inflammation-follicular prevalence. Greater ompA diversity at the district level was associated with increased Ct infection prevalence.<br />Conclusions: We found no evidence for Ct genomic variation contributing to continued transmission of Ct after treatment, adding to evidence that azithromycin does not drive acquisition of macrolide resistance in Ct. Increased Ct infection in areas with more ompA variants requires longitudinal investigation to understand what impact this may have on treatment success and host immunity.<br /> (© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.)
- Subjects :
- Anti-Bacterial Agents therapeutic use
Azithromycin therapeutic use
Chlamydia trachomatis genetics
Drug Resistance, Bacterial genetics
Ethiopia epidemiology
Genomics
Humans
Infant
Infant, Newborn
Macrolides therapeutic use
Prevalence
Gonorrhea drug therapy
Infant, Newborn, Diseases
Trachoma drug therapy
Trachoma epidemiology
Trachoma prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6613
- Volume :
- 225
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 33034349
- Full Text :
- https://doi.org/10.1093/infdis/jiaa615