Back to Search
Start Over
MicroRNAs: roles in cardiovascular development and disease.
- Source :
-
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology [Cardiovasc Pathol] 2021 Jan - Feb; Vol. 50, pp. 107296. Date of Electronic Publication: 2020 Oct 03. - Publication Year :
- 2021
-
Abstract
- Cardiovascular diseases (CVDs) comprise a group of disorders ranging from peripheral artery, coronary artery, cardiac valve, cardiac muscle, and congenital heart diseases to arrhythmias and ultimately, heart failure. For all the advances in therapeutics, CVDs are still the leading cause of mortality the world over, hence the significance of a thorough understanding of CVDs at the molecular level. Disparities in the expressions of genes and microRNAs (miRNAs) play a crucial role in the determination of the fate of cellular pathways, which ultimately affect an organism's physiology. Indeed, miRNAs serve as the regulators of gene expressions in that they perform key functions both in several important cellular pathways and in the regulation of the onset of various diseases such as CVDs. Many miRNAs are expressed in embryonic, postnatal, and adult hearts; their aberrant expression or genetic deletion is associated with abnormal cardiac cell differentiation, disruption in heart development, and cardiac dysfunction. A substantial body of evidence implicates miRNAs in CVD development and suggests them as diagnostic biomarkers and intriguing therapeutic tools. The present review provides an overview of the history, biogenesis, and processing of miRNAs, as well as their function in the development, remodeling, and diseases of the heart.<br /> (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Cardiovascular Diseases physiopathology
Cardiovascular Diseases therapy
Gene Expression Regulation, Developmental
Genetic Markers
Genetic Therapy
Humans
MicroRNAs therapeutic use
Morphogenesis
Cardiovascular Diseases genetics
Cardiovascular System growth & development
MicroRNAs genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1336
- Volume :
- 50
- Database :
- MEDLINE
- Journal :
- Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 33022373
- Full Text :
- https://doi.org/10.1016/j.carpath.2020.107296