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Neuropsychiatric systemic lupus erythematosus with cerebellar vasculitis and obstructive hydrocephalus requiring decompressive craniectomy.
- Source :
-
Modern rheumatology case reports [Mod Rheumatol Case Rep] 2021 Jan; Vol. 5 (1), pp. 52-57. Date of Electronic Publication: 2020 Oct 09. - Publication Year :
- 2021
-
Abstract
- A 36-year-old woman who had been diagnosed with systemic lupus erythematosus (SLE) was admitted to our hospital due to increasing disease SLE activity. Despite the intensification of immunosuppressive treatment, headache newly developed and worsened. Magnetic resonance imaging (MRI) revealed spreading of a high-intensity area along the sulci of the bilateral cerebellar hemispheres. She was diagnosed with neuropsychiatric SLE and methylprednisolone (mPSL) pulse therapy was started. However, consciousness disorder due to cerebellar oedema with obstructive hydrocephalus appeared and required decompressive craniectomy. The histological findings of the biopsy specimens from cerebellar vermis were compatible with features of vasculitis. She was successfully treated adding intravenous cyclophosphamide therapy.
- Subjects :
- Administration, Intravenous
Adult
Cerebellum diagnostic imaging
Cyclophosphamide administration & dosage
Female
Headache etiology
Humans
Hydrocephalus etiology
Immunosuppressive Agents administration & dosage
Lupus Vasculitis, Central Nervous System drug therapy
Magnetic Resonance Imaging
Cerebellum pathology
Decompressive Craniectomy
Hydrocephalus surgery
Lupus Erythematosus, Systemic complications
Lupus Vasculitis, Central Nervous System diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 2472-5625
- Volume :
- 5
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Modern rheumatology case reports
- Publication Type :
- Academic Journal
- Accession number :
- 33021438
- Full Text :
- https://doi.org/10.1080/24725625.2020.1826626