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Recent advances in ultrasound-triggered drug delivery through lipid-based nanomaterials.
- Source :
-
Drug discovery today [Drug Discov Today] 2020 Dec; Vol. 25 (12), pp. 2182-2200. Date of Electronic Publication: 2020 Oct 01. - Publication Year :
- 2020
-
Abstract
- The high prescribed dose of anticancer drugs and their resulting adverse effects on healthy tissue are significant drawbacks to conventional chemotherapy (CTP). Ideally, drugs should have the lowest possible degree of interaction with healthy cells, which would diminish any adverse effects. Therefore, an ideal scenario to bring about improvements in CTP is the use of technological strategies to ensure the efficient, specific, and selective transport and/or release of drugs to the target site. One practical and feasible solution to promote the efficiency of conventional CTP is the use of ultrasound (US). In this review, we highlight the potential role of US in combination with lipid-based carriers to achieve a targeted CTP strategy in engineered smart drug delivery systems.<br /> (Copyright © 2020 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1878-5832
- Volume :
- 25
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Drug discovery today
- Publication Type :
- Academic Journal
- Accession number :
- 33010479
- Full Text :
- https://doi.org/10.1016/j.drudis.2020.09.026