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Short communication: Efficacy of albendazole in Echinococcus multilocularis-infected mice depends on the functional immunity of the host.
- Source :
-
Experimental parasitology [Exp Parasitol] 2020 Dec; Vol. 219, pp. 108013. Date of Electronic Publication: 2020 Oct 01. - Publication Year :
- 2020
-
Abstract
- Alveolar echinococcosis (AE) is a deadly parasitic disease that requires lifelong treatment with albendazole. Development of host immunity is pivotal with regard to the clinical outcome of AE, but its influence on conventional albendazole treatment is unknown. Using T-cell deficient athymic nude mice, we demonstrated that functional immunity is required for albendazole to be efficacious against murine AE. These results call for attention given the increasing number of immunocompromised patients with AE.<br /> (Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Albendazole pharmacology
Animals
Anticestodal Agents pharmacology
Disease Models, Animal
Echinococcosis, Hepatic immunology
Immunocompromised Host
Mice
Mice, Nude
Random Allocation
Albendazole therapeutic use
Anticestodal Agents therapeutic use
Echinococcosis, Hepatic drug therapy
Echinococcus multilocularis drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2449
- Volume :
- 219
- Database :
- MEDLINE
- Journal :
- Experimental parasitology
- Publication Type :
- Academic Journal
- Accession number :
- 33010287
- Full Text :
- https://doi.org/10.1016/j.exppara.2020.108013