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Exploiting Unique Alignment of Cobalt Ferrite Nanoparticles, Mild Hyperthermia, and Controlled Intrinsic Cobalt Toxicity for Cancer Therapy.
- Source :
-
Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2020 Nov; Vol. 32 (45), pp. e2003712. Date of Electronic Publication: 2020 Oct 01. - Publication Year :
- 2020
-
Abstract
- Nanoparticle-based magnetic hyperthermia is a well-known thermal therapy platform studied to treat solid tumors, but its use for monotherapy is limited due to incomplete tumor eradication at hyperthermia temperature (45 °C). It is often combined with chemotherapy for obtaining a more effective therapeutic outcome. Cubic-shaped cobalt ferrite nanoparticles (Co-Fe NCs) serve as magnetic hyperthermia agents and as a cytotoxic agent due to the known cobalt ion toxicity, allowing the achievement of both heat and cytotoxic effects from a single platform. In addition to this advantage, Co-Fe NCs have the unique ability to form growing chains under an alternating magnetic field (AMF). This unique chain formation, along with the mild hyperthermia and intrinsic cobalt toxicity, leads to complete tumor regression and improved overall survival in an in vivo murine xenograft model, all under clinically approved AMF conditions. Numerical calculations identify magnetic anisotropy as the main Co-Fe NCs' feature to generate such chain formations. This novel combination therapy can improve the effects of magnetic hyperthermia, inaugurating investigation of mechanical behaviors of nanoparticles under AMF, as a new avenue for cancer therapy.<br /> (© 2020 The Authors. Published by Wiley-VCH GmbH.)
- Subjects :
- Animals
Cell Line, Tumor
Cobalt adverse effects
Ferric Compounds adverse effects
Humans
Hyperthermia, Induced
Magnetic Fields
Mice
Survival Analysis
Xenograft Model Antitumor Assays
Cobalt chemistry
Cobalt therapeutic use
Ferric Compounds chemistry
Ferric Compounds therapeutic use
Nanoparticles chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1521-4095
- Volume :
- 32
- Issue :
- 45
- Database :
- MEDLINE
- Journal :
- Advanced materials (Deerfield Beach, Fla.)
- Publication Type :
- Academic Journal
- Accession number :
- 33002227
- Full Text :
- https://doi.org/10.1002/adma.202003712