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High-quality nuclear genome for Sarcoptes scabiei-A critical resource for a neglected parasite.
- Source :
-
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2020 Oct 01; Vol. 14 (10), pp. e0008720. Date of Electronic Publication: 2020 Oct 01 (Print Publication: 2020). - Publication Year :
- 2020
-
Abstract
- The parasitic mite Sarcoptes scabiei is an economically highly significant parasite of the skin of humans and animals worldwide. In humans, this mite causes a neglected tropical disease (NTD), called scabies. This disease results in major morbidity, disability, stigma and poverty globally and is often associated with secondary bacterial infections. Currently, anti-scabies treatments are not sufficiently effective, resistance to them is emerging and no vaccine is available. Here, we report the first high-quality genome and transcriptomic data for S. scabiei. The genome is 56.6 Mb in size, has a a repeat content of 10.6% and codes for 9,174 proteins. We explored key molecules involved in development, reproduction, host-parasite interactions, immunity and disease. The enhanced 'omic data sets for S. scabiei represent comprehensive and critical resources for genetic, functional genomic, metabolomic, phylogenetic, ecological and/or epidemiological investigations, and will underpin the design and development of new treatments, vaccines and/or diagnostic tests.<br />Competing Interests: The authors have declared that no competing interests exist.
Details
- Language :
- English
- ISSN :
- 1935-2735
- Volume :
- 14
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- PLoS neglected tropical diseases
- Publication Type :
- Academic Journal
- Accession number :
- 33001992
- Full Text :
- https://doi.org/10.1371/journal.pntd.0008720