Back to Search
Start Over
CD3-CD20-positive nodal lymphoma with cross-lineage rearrangement in a dog.
- Source :
-
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc [J Vet Diagn Invest] 2020 Nov; Vol. 32 (6), pp. 964-967. Date of Electronic Publication: 2020 Oct 01. - Publication Year :
- 2020
-
Abstract
- A 7-y-old mixed-breed male dog was presented with a history of generalized lymphadenopathy. Fine-needle aspirates of the enlarged peripheral lymph nodes were suggestive of lymphoma. Histologic examination of a retromandibular lymph node was suggestive of high-grade, medium large-cell lymphoma. Immunohistochemistry revealed concurrent expression of CD3 and CD20. The co-localization of the 2 antigens was confirmed by immunofluorescence. PCR for antigen receptor gene rearrangements (PARR) detected clonal rearrangements for both T-cell receptor gamma and B-cell receptor. The final diagnosis was CD3-CD20-positive anaplastic lymphoma with cross-lineage rearrangement.
- Subjects :
- Animals
Antigens, CD20 metabolism
CD3 Complex metabolism
Dog Diseases physiopathology
Dogs
Fluorescent Antibody Technique veterinary
Immunohistochemistry
Lymph Nodes pathology
Lymphoma, Large B-Cell, Diffuse diagnosis
Lymphoma, Large B-Cell, Diffuse genetics
Lymphoma, Large B-Cell, Diffuse physiopathology
Male
Antigens, CD20 genetics
CD3 Complex genetics
Dog Diseases diagnosis
Dog Diseases genetics
Gene Rearrangement
Lymphoma, Large B-Cell, Diffuse veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 1943-4936
- Volume :
- 32
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
- Publication Type :
- Academic Journal
- Accession number :
- 33000710
- Full Text :
- https://doi.org/10.1177/1040638720963132