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Focal cortical atrophy following transient meningeal enhancement in a progressive multiple sclerosis.
- Source :
-
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2021 May; Vol. 42 (5), pp. 1959-1961. Date of Electronic Publication: 2020 Sep 29. - Publication Year :
- 2021
-
Abstract
- Recent studies identified chronic leptomeningeal enhancement (LME) in late-acquired FLAIR sequences in secondary progressive (SP) multiple sclerosis (MS). These LMEs correlate with focal cortical inflammation and demyelination observed by pathology, which are supposed to drive long-term cortical atrophy. We report a spontaneously remitting meningeal uptake in a patient suffering from SP MS. No cortical lesion was visible on FLAIR or DIR sequences, but the rate of cortical atrophy was higher in this area. This case suggests that conventional 3-T MRI, by contrary to white matter lesions, may be amnesic with regard to the potential burden of previous regressive meningeal lesions. Moreover, T1-enhanced sequences underscore the real inflammatory activity. LME could be more than passive markers of SP MS, but is also directly responsible for focal cortical atrophy and could be an early manifestation of cortical lesions.
- Subjects :
- Atrophy pathology
Cerebral Cortex diagnostic imaging
Cerebral Cortex pathology
Humans
Magnetic Resonance Imaging
Meninges diagnostic imaging
Meninges pathology
Multiple Sclerosis complications
Multiple Sclerosis diagnostic imaging
Multiple Sclerosis pathology
Multiple Sclerosis, Chronic Progressive pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1590-3478
- Volume :
- 42
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
- Publication Type :
- Academic Journal
- Accession number :
- 32995987
- Full Text :
- https://doi.org/10.1007/s10072-020-04764-0