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Mechanisms of NK cell dysfunction in the tumor microenvironment and current clinical approaches to harness NK cell potential for immunotherapy.
- Source :
-
Journal of leukocyte biology [J Leukoc Biol] 2021 Jun; Vol. 109 (6), pp. 1071-1088. Date of Electronic Publication: 2020 Sep 29. - Publication Year :
- 2021
-
Abstract
- NK cells are innate immune cells with inherent capabilities in both recognizing and killing cancer cells. NK cell phenotypes and functional alterations are being described with increasing precision among patients harboring various cancer types, emphasizing the critical role that NK cells play in antitumor immune responses. In addition, advances in understanding NK cell biology have improved our knowledge of such alterations, thereby expanding the potential exploitation of NK cells' anticancer capabilities. In this review, we present an overview of (1) the various types of NK cell alterations that may contribute to immune evasion in cancer patients and (2) the various strategies to improve NK cell-based anticancer immunotherapies, including pharmacologic modulation and/or genetic modification.<br /> (©2020 Society for Leukocyte Biology.)
- Subjects :
- Animals
Combined Modality Therapy
Humans
Neoplasms pathology
Treatment Outcome
Tumor Escape immunology
Immunotherapy adverse effects
Immunotherapy methods
Killer Cells, Natural immunology
Killer Cells, Natural metabolism
Neoplasms immunology
Neoplasms therapy
Tumor Microenvironment immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1938-3673
- Volume :
- 109
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of leukocyte biology
- Publication Type :
- Academic Journal
- Accession number :
- 32991746
- Full Text :
- https://doi.org/10.1002/JLB.5MR0920-198RR