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Epidemiologic factors in patients with advanced head and neck cancer treated with radiation therapy.
- Source :
-
Head & neck [Head Neck] 2021 Jan; Vol. 43 (1), pp. 164-172. Date of Electronic Publication: 2020 Sep 29. - Publication Year :
- 2021
-
Abstract
- Background: Approximately 50% of patients with head and neck cancer (HNC) initially were seen with advanced disease. We aimed to evaluate the association of epidemiologic factors with advanced HNC at diagnosis.<br />Methods: The OraRad multicenter prospective cohort study enrolled HNC patients receiving curative-intent radiation therapy. Factors assessed for association with advanced HNC presentation at diagnosis included demographics, social and medical history, cancer characteristics, human papilloma virus (HPV) status, and dental disease measures.<br />Results: We enrolled 572 participants; 77% male and mean (SD) age of 61.7 (11.2) years. Oropharyngeal squamous cell carcinomas (88% HPV-related) were seen with smaller tumors, but more frequent nodal involvement. Private medical insurance and no Medicaid were associated with smaller tumors. A higher dental disease burden was associated with larger tumors.<br />Conclusions: Insurance status, cancer type/location, and dental disease are associated with advanced HNC and may represent potentially modifiable factors or factors to be considered in the screening process of new lesions.<br /> (© 2020 The Authors. Head & Neck published by Wiley Periodicals LLC.)
Details
- Language :
- English
- ISSN :
- 1097-0347
- Volume :
- 43
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Head & neck
- Publication Type :
- Academic Journal
- Accession number :
- 32991009
- Full Text :
- https://doi.org/10.1002/hed.26468