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Microwave assisted fast fabrication of zinc/iron oxides based polymeric nanocomposites and evaluation on equine fibroblasts.
- Source :
-
International journal of biological macromolecules [Int J Biol Macromol] 2020 Dec 15; Vol. 165 (Pt A), pp. 71-81. Date of Electronic Publication: 2020 Sep 25. - Publication Year :
- 2020
-
Abstract
- We aimed to provide a tissue repair material, which can be synthesized rapidly, using polymers mimicking the natural environment in the extra-cellular matrix and metals/minerals. The components should have the potential to be used in tissue repair and simultaneously, reducing the side-effects of the incorporated molecules. It is challenging to manage the dispersibility of ZnO NPs in common solutions like water. Here, we report a novel method for preparing highly dispersible suspensions of ZnO NPs. In contrast to those synthesized by conventional methods, microwave assisted method allowed synthesis of dispersible ZnO NPs and the incorporation of zinc/Iron oxides NPs within alginate and gum matrix (AG) in a short span of time providing high yield of the product. The nanoformulations were characterized for size, morphology, interaction of various chemicals used during their synthesis by transmissible electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy and energy dispersive X ray Spectrum. It was also evaluated for cytotoxicity and their effect on equine fibroblast cells. Microwave-assisted fabrication of zinc/iron oxides nanoparticles provided flowerlike morphology with good dispersibility and high yield in a short span of time. Our results revealed that ZnO NPs were more cytotoxic than AG ZnO NPs and doped AG Fe <subscript>3</subscript> O <subscript>4</subscript> doped ZnO NPs at higher concentrations. Further metal nanoparticles capped with alginate/acacia with size range less than 100 nm demonstrated high stability, good biocompatibility, re-epithelization and enhanced mineralization in horse fibroblast cells.<br />Competing Interests: Declaration of competing interest The authors declare no conflict of interest.<br /> (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Ferric Compounds pharmacology
Ferric Compounds radiation effects
Fibroblasts drug effects
Horses
Metal Nanoparticles radiation effects
Microscopy, Electron, Scanning
Microwaves
Nanocomposites radiation effects
Spectroscopy, Fourier Transform Infrared
Zinc Oxide pharmacology
Zinc Oxide radiation effects
Ferric Compounds chemistry
Metal Nanoparticles chemistry
Nanocomposites chemistry
Zinc Oxide chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0003
- Volume :
- 165
- Issue :
- Pt A
- Database :
- MEDLINE
- Journal :
- International journal of biological macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 32987081
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2020.09.172