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High sensitivity Troponin-T for prediction of adverse events in patients with COVID-19.
- Source :
-
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals [Biomarkers] 2020 Dec; Vol. 25 (8), pp. 626-633. Date of Electronic Publication: 2020 Nov 24. - Publication Year :
- 2020
-
Abstract
- Background: High sensitivity cardiac troponin-T (hs-TnT) has been associated with mortality in patients hospitalized with COVID-19. We aimed to determine if hs-TnT levels and their timing are independent predictors of adverse events in these patients.<br />Design: Retrospective chart review was performed for all patients hospitalized at our institution between 23 March 2020 and 13 April 2020 who were found to be COVID-19-positive. Clinical, demographic, and laboratory variables including initial and peak hs-TnT were recorded. Univariable and multivariable analyses were completed for a primary composite endpoint of in-hospital death, intubation, need for critical care, or cardiac arrest.<br />Results: In the 276 patients analysed, initial hs-TnT above the median (≥17 ng/L) was associated with increased length of stay, need for vasoactive medications, and death, along with the composite endpoint (OR 3.92, p < 0.001). Multivariable analysis demonstrated that elevated initial hs-TnT was independently associated with the primary endpoint (OR 2.92, p = 0.01). Late-peaking hs-TnT (OR 2.19 for each additional day until peak, p < 0.001) was also independently associated with the composite endpoint.<br />Conclusions: In patients hospitalized with COVID-19, hs-TnT identifies patients at high risk for adverse in-hospital events, and trends of hs-TnT over time, particularly during the first day, provide additional prognostic information.
- Subjects :
- Aged
Aged, 80 and over
COVID-19 epidemiology
COVID-19 virology
Female
Humans
Male
Middle Aged
Pandemics
Predictive Value of Tests
Prognosis
Retrospective Studies
Risk Assessment methods
Risk Assessment statistics & numerical data
Risk Factors
SARS-CoV-2 physiology
Sensitivity and Specificity
Biomarkers blood
COVID-19 blood
Troponin T blood
Subjects
Details
- Language :
- English
- ISSN :
- 1366-5804
- Volume :
- 25
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
- Publication Type :
- Academic Journal
- Accession number :
- 32981387
- Full Text :
- https://doi.org/10.1080/1354750X.2020.1829056