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The relation between distant metastasis and genetic change type in stage IV lung adenocarcinoma patients at diagnosis.

Authors :
Ermin S
Batum Ö
Saka Güvenç M
Diniz G
Ayrancı A
Erdoğan KM
Yücel N
Yıldırım E
Özdemir TR
Hacar AG
Güldaval F
Koç A
Aydoğdu Z
Balcı G
Özyılmaz B
Akşit Yaşar H
Özer Kaya Ö
Gayaf M
Kırbıyık Ö
Aksel N
Kutbay YB
Ursavaş TN
Karadeniz G
Polat G
Kömürcüoğlu B
Çırak AK
Yılmaz U
Source :
The clinical respiratory journal [Clin Respir J] 2021 Feb; Vol. 15 (2), pp. 196-202. Date of Electronic Publication: 2020 Oct 12.
Publication Year :
2021

Abstract

Introduction: Brain metastasis prevalence is higher in patients with positive epidermal growth factor receptor (EGFR) mutation, anaplastic lymphoma kinase (ALK) and C-ROS oncogene 1 (ROS-1) fusion change in lung adenocarcinoma.<br />Objectives: The purpose of our study is to investigate the relation between the genetic change type and the initial distant metastasis in stage IV lung adenocarcinoma patients with genetic changes.<br />Methods: The study was conducted between January 2007 and December 2018 in a retrospective fashion with patients who had lung cancer diagnosed as stage IV adenocarcinoma. The relation between genetic mutation change (EGFR, ALK or ROS-1) and distant metastasis was analysed.<br />Results: A total of 845 patients were included in the study. The median age was 62 (28-88). It was determined that lung and pleura metastases were more frequent at a significant level in patients with positive EGFR mutation (P = 0.032, P = 0.004, respectively). In patients with positive ALK fusion change, pleura metastasis was determined to be more frequent (P = 0.001). Multiple metastases were determined to be significantly more in patients with positive ALK fusion change than single metastasis (P = 0.02).<br />Conclusion: In patients with EGFR mutant lung adenocarcinoma, lung and pleura metastasis is more frequent and pleura metastasis is more frequent in ALK positive adenocarcinoma. Additionally, multiple organ metastases are higher in ALK positive lung adenocarcinoma.<br /> (© 2020 John Wiley & Sons Ltd.)

Details

Language :
English
ISSN :
1752-699X
Volume :
15
Issue :
2
Database :
MEDLINE
Journal :
The clinical respiratory journal
Publication Type :
Academic Journal
Accession number :
32981210
Full Text :
https://doi.org/10.1111/crj.13284