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Trigeminal Neuralgia Crisis - Intravenous Phenytoin as Acute Rescue Treatment.
- Source :
-
Headache [Headache] 2020 Nov; Vol. 60 (10), pp. 2247-2253. Date of Electronic Publication: 2020 Sep 27. - Publication Year :
- 2020
-
Abstract
- Objective: The aim of this retrospective cohort study was to analyze responses to intravenous (IV) phenytoin (PHT) for trigeminal neuralgia (TN) crisis in a group of patients treated at our institution.<br />Background: TN is one of the most common causes of facial pain. Its treatment relies on preventive therapy with either carbamazepine or oxcarbazepine. During severe pain episodes, patients may be unable to eat, drink, or even swallow oral medication, requiring in-hospital treatment. There is scarce evidence to support IV medication use for TN, making management of this condition difficult.<br />Methods: We reviewed clinical records of patients with TN crisis consulting the emergency department at a tertiary neurological referral center in Buenos Aires, Argentina, treated with IV PHT as analgesic strategy, and with at least 1-month posttreatment follow-up. Demographic features, magnetic resonance imaging findings, and therapeutic management were analyzed.<br />Results: Thirty-nine patients with TN were included, 18 (46.2%) receiving IV PHT more than once (total number of infusions administered, 65). Immediate pain relief was observed in 89.2% (58/65) and 15.4% (10/65) presented side effects.<br />Conclusions: We recommend IV PHT as acute rescue treatment in TN crisis.<br /> (© 2020 American Headache Society.)
- Subjects :
- Acute Disease
Adult
Aged
Female
Follow-Up Studies
Humans
Infusions, Intravenous
Male
Middle Aged
Phenytoin administration & dosage
Phenytoin adverse effects
Retrospective Studies
Tertiary Care Centers
Voltage-Gated Sodium Channel Blockers administration & dosage
Voltage-Gated Sodium Channel Blockers adverse effects
Outcome Assessment, Health Care
Phenytoin pharmacology
Trigeminal Neuralgia drug therapy
Voltage-Gated Sodium Channel Blockers pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1526-4610
- Volume :
- 60
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Headache
- Publication Type :
- Academic Journal
- Accession number :
- 32981076
- Full Text :
- https://doi.org/10.1111/head.13963