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Critical role of IL-33, but not IL-25 or TSLP, in silica crystal-mediated exacerbation of allergic airway eosinophilia.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Dec 10; Vol. 533 (3), pp. 493-500. Date of Electronic Publication: 2020 Sep 22. - Publication Year :
- 2020
-
Abstract
- Silica crystals (silica), which are a major mineral component of volcanic ash and desert dust, contribute to the pathogenesis of pulmonary disorders such as asthma and fibrosis. Although administration of silica or sand dust to rodents exacerbates development of ovalbumin-induced or house dust mite-induced asthma-like airway inflammation, the detailed mechanisms remain unclear. Here, using murine models, we found that silica can induce IL-33 expression in pulmonary epithelial cells. IL-33, but not IL-25 or TSLP, and type 2 cytokines such as IL-5 and IL-13 were critically involved in silica's exacerbation of OVA-induced airway eosinophilia in mice. Innate lymphoid cells (ILCs), but not T, B or NKT cells, were also involved in the setting. Moreover, a scavenger receptor that recognized silica was important for silica's exacerbating effect. These observations suggest that IL-33 induced in epithelial cells by silica activates ILCs to produce IL-5 and/or IL-13, contributing to silica's exacerbation of OVA-induced airway eosinophilia in mice. Our findings provide new insight into the underlying mechanisms of exacerbation of pulmonary disorders such as asthma following inhalation of silica-containing materials such as volcanic ash and desert dust.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Asthma immunology
Cytokines physiology
Interleukin-13 physiology
Interleukin-33 biosynthesis
Interleukin-5 physiology
Interleukins physiology
Lung drug effects
Lung immunology
Lung pathology
Mice, Inbred BALB C
Mice, Inbred C57BL
Ovalbumin immunology
Pneumonia immunology
Pneumonia pathology
Pulmonary Eosinophilia chemically induced
Receptors, Scavenger physiology
Thymic Stromal Lymphopoietin
Interleukin-33 physiology
Pulmonary Eosinophilia immunology
Silicon Dioxide toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2104
- Volume :
- 533
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 32977946
- Full Text :
- https://doi.org/10.1016/j.bbrc.2020.09.046