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Growth Differentiation Factor 15 Ameliorates Anti-Glomerular Basement Membrane Glomerulonephritis in Mice.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2020 Sep 23; Vol. 21 (19). Date of Electronic Publication: 2020 Sep 23. - Publication Year :
- 2020
-
Abstract
- Growth differentiation factor 15 (GDF15) is a member of the transforming growth factor-β (TGF-β) cytokine family and an inflammation-associated protein. Here, we investigated the role of GDF15 in murine anti-glomerular basement membrane (GBM) glomerulonephritis. Glomerulonephritis induction in mice induced systemic expression of GDF15. Moreover, we demonstrate the protective effects for GDF15, as GDF15-deficient mice exhibited increased proteinuria with an aggravated crescent formation and mesangial expansion in anti-GBM nephritis. Herein, GDF15 was required for the regulation of T-cell chemotactic chemokines in the kidney. In addition, we found the upregulation of the CXCR3 receptor in activated T-cells in GDF15-deficient mice. These data indicate that CXCL10/CXCR3-dependent-signaling promotes the infiltration of T cells into the organ during acute inflammation controlled by GDF15. Together, these results reveal a novel mechanism limiting the migration of lymphocytes to the site of inflammation during glomerulonephritis.
- Subjects :
- Animals
Cell Movement genetics
Chemokine CXCL10 genetics
Chemokine CXCL10 immunology
Glomerular Basement Membrane pathology
Glomerulonephritis, Membranous genetics
Glomerulonephritis, Membranous pathology
Growth Differentiation Factor 15 genetics
Mice
Mice, Knockout
Proteinuria genetics
Proteinuria pathology
Receptors, CXCR3 genetics
Receptors, CXCR3 immunology
T-Lymphocytes pathology
Cell Movement immunology
Glomerular Basement Membrane immunology
Glomerulonephritis, Membranous immunology
Growth Differentiation Factor 15 immunology
Proteinuria immunology
T-Lymphocytes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 21
- Issue :
- 19
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 32977372
- Full Text :
- https://doi.org/10.3390/ijms21196978