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Early decrease in intermediate monocytes in peripheral blood is characteristic of multiple system atrophy-cerebellar type.
- Source :
-
Journal of neuroimmunology [J Neuroimmunol] 2020 Dec 15; Vol. 349, pp. 577395. Date of Electronic Publication: 2020 Sep 20. - Publication Year :
- 2020
-
Abstract
- To identify biomarkers for multiple system atrophy-cerebellar type (MSA-C), we used flow cytometry to measure surface marker expression of peripheral blood monocytes from patients with MSA-C or hereditary spinocerebellar degeneration (hSCD) and from healthy controls (HCs). The percentage of intermediate monocytes was significantly lower in MSA-C patients than in hSCD patients and HCs and showed significant positive correlations with disease duration and unified MSA rating scale scores. The percentage of CD62L <superscript>+</superscript> intermediate monocytes was significantly lower in MSA-C patients than in hSCD patients and HCs. Early decrease of peripheral blood intermediate monocytes is characteristic of MSA-C and is a biomarker.<br /> (Copyright © 2020 Elsevier B.V. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1872-8421
- Volume :
- 349
- Database :
- MEDLINE
- Journal :
- Journal of neuroimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 32977251
- Full Text :
- https://doi.org/10.1016/j.jneuroim.2020.577395