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COVID-19 and Guillain-Barré Syndrome: A Case Report and Review of Literature.
- Source :
-
Frontiers in neurology [Front Neurol] 2020 Aug 21; Vol. 11, pp. 909. Date of Electronic Publication: 2020 Aug 21 (Print Publication: 2020). - Publication Year :
- 2020
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Abstract
- During the recent coronavirus disease 2019 (COVID-19) outbreak in Northern Italy, we observed a 57-year-old man developing acute motor-sensory axonal neuropathy, a variant of Guillain-Barré syndrome (GBS), 12 days after severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection. Similarly to other bacterial and viral infections, dysregulation of the immune system due to post-infectious mechanisms, such as the molecular mimicry, could lead to an indirect damage of the peripheral nervous system related to SARS-CoV-2. GBS causes motor dysfunctions that are not easily recognizable in non-neurological settings or in patients requiring ventilatory assistance. Several reports also suggested that GBS and Miller Fisher syndrome (MFS) could be neurological complications of COVID-19. Therefore, we performed a review of the 29 articles so far published, describing 33 GBS cases and five MFS cases associated with SARS-CoV-2 infection. We recommend awareness of this rare, but treatable, neurological syndrome, which may also determine a sudden and otherwise unexplained respiratory deterioration in COVID-19 patients.<br /> (Copyright © 2020 Zito, Alfonsi, Franciotta, Todisco, Gastaldi, Cotta Ramusino, Ceroni and Costa.)
Details
- Language :
- English
- ISSN :
- 1664-2295
- Volume :
- 11
- Database :
- MEDLINE
- Journal :
- Frontiers in neurology
- Publication Type :
- Report
- Accession number :
- 32973665
- Full Text :
- https://doi.org/10.3389/fneur.2020.00909